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In a 2025 observational cohort, the Risk of Vestibular Disorders with Semaglutide and Tirzepatide study reported dizziness in 18% of semaglutide users compared with 10% in the control group, indicating a higher-than-baseline incidence and reinforcing the need to monitor for dose- or timing-related patterns

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Peer review Peer review information Nature Reviews Drug Discovery thanks Michael Nauck, Stefan Trapp and the other, anonymous, reviewer(s) for their contribution to the peer review of this work